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Dissecting the role of acetaldehyde in oral carcinogenesis

Status: Recruiting

The goal of this study is to better understand how drinking alcohol may lead to oral cancers. Acetaldehyde, a chemical formed when the body breaks down alcohol, is believed to play an important role. This study will measure acetaldehyde and DNA damage levels in the mouth of participants after a low dose of alcohol. The levels will be compared between three groups, all having different degrees of risk for developing oral cancer, in order to identify DNA damage that might be crucial to cancer formation.

I'm interested

Age: 18 years and over
Healthy Volunteers:
This study is also accepting healthy volunteers
Inclusion Criteria:

• Alcohol drinkers of Eastern Asian descent who experiences flushing (reddening or warming of face) when drinking {ages 21 - 45}
• Alcohol drinkers who have Fanconi Anemia {ages 21+}
• Never drinkers {ages 18 - 45}
Exclusion Criteria:

• Tobacco or nicotine users
Interventions:

Drug: Alcohol, Procedure: Biospecimen Collection, Procedure: Breath Test

Conditions:

Prevention & Wellness

Keywords:

Alcohol, drinking, Fanconi Anemia

Contact(s): Alcohol Study - alcohol-study@umn.edu
Principal Investigator: Silvia Balbo
Phase: NA
IRB Number: STUDY00012972
System ID: 33324
See this study on ClinicalTrials.gov

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